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Title   간외담도암에서 p53 발현의 의의 ( Significance of p53 Overexpression in Extrahepatic Bile Duct Cancer )
Publicationinfo   1993 Jan; 025(06): 873-878.
Key_word   Bile duct cancer, p53
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Abstract   We investigated overexpression of p53 and its clinical significance in a series of 37 extrahepatic bile duct cancer. Deparaffinized sections of formalinfixed tumor tissue samples taken from patients during 5 year period from l986 to 1990 were immunostained for p53 protein, using mouse anti-human p53 protein monoclonal antibody(Novocastra Lab.-NCL-DO7, IgG2b, 1: 100). Immunohistochemically detected p53 overexperssion was found in 32.4%(twelve cases) of 37 resected extrahepatic bile duct tumors. No immunostaining was found in adiacent normal tissues. There was no difference between p53 negative group and p53 overexpression group in clinico-pathologic characteristics including sex, extent of diseese, histologic and gross types, location of tumor. The patients were analysed for survival time according to the extent of disease and p53 positivity. Prognosis of p53 positive and p53 negative group did not show any significant difference. This study has shown that one third of extrahepatic bile duct cancers had immunohistochemically detectable p53 overexpression and in this study we have not found any evidence of clinical or prognostic significance of p53 overexpression in cancers of extrahepatic bile duct.
저 자   김선회(Sun Whe Kim),김우호(Woo Ho Kim),박용현(Yong Hyun Park)